Issue 20, 2005
From the journal:

Chemical Communications

The rhodium catalyzed three-component reaction of diazoacetates, titanium(iv) alkoxides and aldehydes†

Chong-Dao Lu,ab   Hui Liu,a   Zhi-Yong Chen,a   Wen-Hao Hu*a  and  Ai-Qiao Mia  

* Corresponding authors

a Key Laboratory for Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
E-mail: huwh@cioc.ac.cn

b Graduate School of the Chinese Academy of Sciences, China

Abstract

The rhodium(II)-catalyzed three-component reaction of diazoacetates, titanium alkoxides and aldehydes is shown to give α-alkoxyl-β-hydroxyl acid derivatives; the novel C–C bond formation reaction is proposed to occur through oxonium ylides derived from diazo compounds and titanium alkoxides, and followed by intermolecular trapping by aldehydes.

Graphical abstract: The rhodium catalyzed three-component reaction of diazoacetates, titanium(iv) alkoxides and aldehydes

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Article information

DOI
https://doi.org/10.1039/B502093J
Article type
Communication
Submitted
10 Feb 2005
Accepted
22 Mar 2005
First published
06 Apr 2005

Chem. Commun., 2005, 2624-2626

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The rhodium catalyzed three-component reaction of diazoacetates, titanium(IV) alkoxides and aldehydes

C. Lu, H. Liu, Z. Chen, W. Hu and A. Mi, Chem. Commun., 2005, 2624 DOI: 10.1039/B502093J

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