Issue 23, 2005
From the journal:

Chemical Communications

In situ hybridization of PNA/DNA studied label-free by electrochemical impedance spectroscopy†

Jianyun Liu,a   Shengjun Tian,a   Peter E. Nielsenb  and  Wolfgang Knoll*a  

* Corresponding authors

a Max-Planck-Institute for Polymer Research, Ackermannweg 10, Mainz, Germany
E-mail: knoll@mpip-mainz.mpg.de
Fax: +49-6131-379360
Tel: +49-6131-379160

b Center for Biomolecular Recognition, Department for Biochemistry and Genetics, Biochemistry Laboratory B, The Panum Institute, Blegdamsvej 3c, Copenhagen, Denmark

Abstract

The in situ hybridization kinetics of label-free DNA on mixed monolayers of peptide nucleic acid (PNA) and 6-mercapto-1-hexanol (MCH) on Au electrodes was investigated by electrochemical impedance spectroscopy (EIS) and used to discriminate the fully complementary DNA from the single-base mismatched hybrids.

Graphical abstract: In situ hybridization of PNA/DNA studied label-free by electrochemical impedance spectroscopy

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Article information

DOI
https://doi.org/10.1039/B419425J
Article type
Communication
Submitted
05 Jan 2005
Accepted
13 Apr 2005
First published
29 Apr 2005

Chem. Commun., 2005, 2969-2971

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In situ hybridization of PNA/DNA studied label-free by electrochemical impedance spectroscopy

J. Liu, S. Tian, P. E. Nielsen and W. Knoll, Chem. Commun., 2005, 2969 DOI: 10.1039/B419425J

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