Issue 16, 2005
From the journal:

Chemical Communications

Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium (ii) acetate and tetra-n-butylammonium salts†

Connie K. Y. Lee,a   Andrew B. Holmes,*ab   Steven V. Ley,*a   Ian F. McConvey,c   Bushra Al-Duri,d   Gary A. Leeke,d   Regina C. D. Santosd  and  Jonathan P. K. Sevilled  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: abh1@cam.ac.uk, aholmes@unimelb.edu.au, svl1000@cam.ac.uk
Fax: +44 1223 334866
Tel: +44 1223 334370

b Bio21 Institute, University of Melbourne, Parkville, Vic. 3010, Australia

c AstraZeneca Process Research and Development, Macclesfield, Cheshire, UK

d Department of Chemical Engineering, University of Birmingham, Birmingham, UK

Abstract

Suzuki cross-coupling reactions are effected in both conventional organic solvents, under continuous flow conditions at 70 °C, and in batch mode in supercritical carbon dioxide (scCO2), at temperatures as low as 40 °C in the presence of palladium(II) acetate microencapsulated in polyurea [PdEnCat]™ and tetra-n-butylammonium salts.

Graphical abstract: Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium (ii) acetate and tetra-n-butylammonium salts

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Article information

DOI
https://doi.org/10.1039/B418669A
Article type
Communication
Submitted
14 Dec 2004
Accepted
04 Feb 2005
First published
09 Mar 2005

Chem. Commun., 2005, 2175-2177

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Efficient batch and continuous flow Suzuki cross-coupling reactions under mild conditions, catalysed by polyurea-encapsulated palladium (II) acetate and tetra-n-butylammonium salts

C. K. Y. Lee, A. B. Holmes, S. V. Ley, I. F. McConvey, B. Al-Duri, G. A. Leeke, R. C. D. Santos and J. P. K. Seville, Chem. Commun., 2005, 2175 DOI: 10.1039/B418669A

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