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Issue 16, 2005
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The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides

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Abstract

Two alternative approaches to the synthesis of novel 6-(fluoromethyl)purine bases and nucleosides are described either by direct deoxyfluorination or by multistep functional group transformations starting from 6-(hydroxymethyl)purines. 6-(Fluoromethyl)purine ribonucleoside displayed significant cytostatic effects.

Graphical abstract: The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides

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Article information


Submitted
08 Jun 2005
Accepted
09 Jun 2005
First published
04 Jul 2005

Org. Biomol. Chem., 2005,3, 3001-3007
Article type
Paper

The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosides

P. Šilhár, R. Pohl, I. Votruba and M. Hocek, Org. Biomol. Chem., 2005, 3, 3001
DOI: 10.1039/B508122J

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