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Issue 14, 2005
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Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives

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Abstract

Stereospecific syntheses of the ZE and EZ vinylogues of combretastatin A-4, and two B-ring related analogues, were achieved through a Suzuki–Miyaura coupling. As compared to CA4, the derivative with a phenyl moiety has shown increased potency in its ability to inhibit tubulin polymerisation.

Graphical abstract: Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives

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Article information


Submitted
28 Apr 2005
Accepted
26 May 2005
First published
21 Jun 2005

Org. Biomol. Chem., 2005,3, 2657-2660
Article type
Paper

Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives

J. Kaffy, R. Pontikis, J. Florent and C. Monneret, Org. Biomol. Chem., 2005, 3, 2657
DOI: 10.1039/B505955K

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