Issue 16, 2005
From the journal:

Organic & Biomolecular Chemistry

Synthesis and stability of exocyclic triazine nucleosides

Michelle Hysell,a   Jay S. Siegel*b  and  Yitzhak Tor*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California, La Jolla, San Diego, California 92093-0358
E-mail: ytor@ucsd.edu

b Institute for Organic Chemistry, University of Zürich, Winterthürerstrasse 190, CH-8006 Zürich, Switzerland
E-mail: jss@oci.unizh.ch

Abstract

Synthesis and stability studies of exocyclic amino triazine nucleosides were performed. Stability of the nucleosides was found to be dependent on triazine ring electron density, solvent, and pH. The nucleosides were found to be more stable when the triazine ring was electron deficient, in high pH aqueous solutions and in aprotic solvents.

Graphical abstract: Synthesis and stability of exocyclic triazine nucleosides

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Article information

DOI
https://doi.org/10.1039/B503757C
Article type
Paper
Submitted
14 Mar 2005
Accepted
18 May 2005
First published
19 Jul 2005

Org. Biomol. Chem., 2005,3, 2946-2952

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Synthesis and stability of exocyclic triazine nucleosides

M. Hysell, J. S. Siegel and Y. Tor, Org. Biomol. Chem., 2005, 3, 2946 DOI: 10.1039/B503757C

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