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Issue 9, 2005
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Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies

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Abstract

Alkylation of the peroxyhemiketal function is described and all synthesised endoperoxides show good antimalarial activity. New rearrangement reactions in the presence of CsCO3, and preliminary results on Fe(II) chemical reduction of the O–O bond are presented.

Graphical abstract: Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies

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Article information


Submitted
08 Mar 2005
Accepted
16 Mar 2005
First published
04 Apr 2005

Org. Biomol. Chem., 2005,3, 1612-1614
Article type
Communication

Alkylation of natural endoperoxide G3-factor. Synthesis and antimalarial activity studies

F. Najjar, L. Gorrichon, M. Baltas, C. André-Barrès and H. Vial, Org. Biomol. Chem., 2005, 3, 1612
DOI: 10.1039/B503402G

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