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Issue 12, 2005
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A novel crossed microfluidic device for the precise positioning of proteins and vesicles

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Abstract

Herein we present a novel way to create arrays of different proteins or lipid vesicles using a crossed microfluidic device. The concept relies on the combination of I) a designated two-step surface chemistry, which allows activation for subsequent binding events, and II) crossing microfluidic channels for the local functionalization by separated laminar streams. Besides its simplicity and cost efficiency, this concept has the advantage that it keeps the proteins in a hydrated environment throughout the experiment. We have demonstrated the feasibility of such a device to create a chessboard pattern of different fluorescently labeled lipid vesicles, which offers the possibility to contain biomolecules, drugs or membrane proteins.

Graphical abstract: A novel crossed microfluidic device for the precise positioning of proteins and vesicles

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Article information


Submitted
13 Jul 2005
Accepted
13 Sep 2005
First published
05 Oct 2005

Lab Chip, 2005,5, 1387-1392
Article type
Paper

A novel crossed microfluidic device for the precise positioning of proteins and vesicles

M. R. Dusseiller, B. Niederberger, B. Städler, D. Falconnet, M. Textor and J. Vörös, Lab Chip, 2005, 5, 1387
DOI: 10.1039/B509957A

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