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Issue 10, 2005
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An integrated microfluidic device for influenza and other genetic analyses

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Abstract

An integrated microfluidic device capable of performing a variety of genetic assays has been developed as a step towards building systems for widespread dissemination. The device integrates fluidic and thermal components such as heaters, temperature sensors, and addressable valves to control two nanoliter reactors in series followed by an electrophoretic separation. This combination of components is suitable for a variety of genetic analyses. As an example, we have successfully identified sequence-specific hemagglutinin A subtype for the A/LA/1/87 strain of influenza virus. The device uses a compact design and mass production technologies, making it an attractive platform for a variety of widely disseminated applications.

Graphical abstract: An integrated microfluidic device for influenza and other genetic analyses

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Article information


Submitted
04 May 2005
Accepted
22 Jul 2005
First published
18 Aug 2005

Lab Chip, 2005,5, 1024-1032
Article type
Paper

An integrated microfluidic device for influenza and other genetic analyses

R. Pal, M. Yang, R. Lin, B. N. Johnson, N. Srivastava, S. Z. Razzacki, K. J. Chomistek, D. C. Heldsinger, R. M. Haque, V. M. Ugaz, P. K. Thwar, Z. Chen, K. Alfano, M. B. Yim, M. Krishnan, A. O. Fuller, R. G. Larson, D. T. Burke and M. A. Burns, Lab Chip, 2005, 5, 1024
DOI: 10.1039/B505994A

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