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Issue 3, 2005
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Computer-aided organic synthesis

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It is tempting for those in the field of organic synthesis to liken the process of retrosynthesis to a game of chess. That the world chess champion was recently defeated by a computer leads us to think that perhaps new and powerful computing methods could be applied to synthetic problems. Here the analogy between synthesis and chess is outlined. Achievements in the 35-year history of computer-aided synthetic design are described, followed by some more recent developments.

Graphical abstract: Computer-aided organic synthesis

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Article information

10 Sep 2004
First published
08 Feb 2005

Chem. Soc. Rev., 2005,34, 247-266
Article type
Tutorial Review

Computer-aided organic synthesis

M. H. Todd, Chem. Soc. Rev., 2005, 34, 247
DOI: 10.1039/B104620A

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