Issue 27, 2005
From the journal:

Chemical Communications

Stereoselective γ-lactam synthesis viapalladium-catalysed intramolecular allylation†

Donald Craig,*a   Christopher J. T. Hylanda  and  Simon E. Wardb  

* Corresponding authors

a Department of Chemistry, Imperial College London, South Kensington Campus, London, UK
E-mail: d.craig@imperial.ac.uk
Fax: +44 (0)20 7594 5868
Tel: +44 (0)20 7594 5771

b GlaxoSmithKline Research Ltd, New Frontiers Science Park North, Third Avenue, Harlow, Essex, UK
E-mail: simon.e.ward@gsk.com
Fax: +44(0)1279 622895
Tel: +44 (0)1279 627728

Abstract

A novel route to the synthesis of 3-(tolylsulfonyl)-4,5-cis-disubstituted γ-lactams using a diastereoselective palladium-catalysed intramolecular allylation of amino acid-derived allylic carbonates has been developed.

Graphical abstract: Stereoselective γ-lactam synthesis via palladium-catalysed intramolecular allylation

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Article information

DOI
https://doi.org/10.1039/B504731E
Article type
Communication
Submitted
07 Mar 2005
Accepted
11 May 2005
First published
09 Jun 2005

Chem. Commun., 2005, 3439-3441

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Stereoselective γ-lactam synthesis via palladium-catalysed intramolecular allylation

D. Craig, C. J. T. Hyland and S. E. Ward, Chem. Commun., 2005, 3439 DOI: 10.1039/B504731E

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