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Issue 34, 2005
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The enzymology of clavam and carbapenem biosynthesis

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Abstract

The enzyme-catalysed reactions involved in formation of the bicyclic clavam and carbapenem nuclei, including β-amino acid and β-lactam formation, are discussed and compared with those involved in penicillin and cephalosporin biosynthesis. The common role of unusual oxidation reactions in the biosynthetic pathways and the lack of synthetic reagents available to effect them are highlighted.

Graphical abstract: The enzymology of clavam and carbapenem biosynthesis

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Article information


Submitted
27 Apr 2005
Accepted
08 Jul 2005
First published
08 Aug 2005

Chem. Commun., 2005, 4251-4263
Article type
Feature Article

The enzymology of clavam and carbapenem biosynthesis

N. J. Kershaw, M. E. C. Caines, M. C. Sleeman and C. J. Schofield, Chem. Commun., 2005, 4251
DOI: 10.1039/B505964J

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