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Issue 4, 2005
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Alexa Fluor 488 as an iron sensing molecule and its application in PEBBLE nanosensors

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Abstract

Molecular Probes' Alexa Fluor dyes are generally used for biological labeling because of their ideal fluorescent properties, but here we detail Alexa Fluor 488's nanomolar sensitivity to free iron. Furthermore, the dye has been encapsulated into a polymer nanosphere by a microemulsion method, producing <100 nm particles. These nanosensors, PEBBLEs (Probe Encapsulated By Biologically Localized Embedding) have micromolar sensitivity and are non-responsive to other metal ions of biological interest.

Graphical abstract: Alexa Fluor 488 as an iron sensing molecule and its application in PEBBLE nanosensors

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Publication details

The article was received on 14 Sep 2004, accepted on 03 Feb 2005 and first published on 25 Feb 2005


Article type: Paper
DOI: 10.1039/B414189J
Analyst, 2005,130, 528-533

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    Alexa Fluor 488 as an iron sensing molecule and its application in PEBBLE nanosensors

    J. P. Sumner and R. Kopelman, Analyst, 2005, 130, 528
    DOI: 10.1039/B414189J

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