Issue 19, 2004
From the journal:

Organic & Biomolecular Chemistry

A simple solid phase diversity linker strategy using enol phosphonates†

Ian B. Campbell,a   Jun Guo,b   Edward Jonesb  and  Patrick. G. Steel*b  

* Corresponding authors

a GlaxoSmithKline, Gunnels Wood Road, Stevenage, Herts., UK

b Department of Chemistry, University of Durham, Science Laboratories, South Road, Durham, UK
E-mail: p.g.steel@durham.ac.uk

Abstract

Polymer bound lactam enol phosphonates can be easily generated using simple phenol on polystyrene resin. These stable, storable compounds can be released in a diversity cleavage strategy, using Suzuki cross coupling conditions, to provide 2-arylenamides in moderate to good overall yields.

Graphical abstract: A simple solid phase diversity linker strategy using enol phosphonates

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Article information

DOI
https://doi.org/10.1039/B411111G
Article type
Communication
Submitted
22 Jul 2004
Accepted
16 Aug 2004
First published
01 Sep 2004

Org. Biomol. Chem., 2004,2, 2725-2727

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A simple solid phase diversity linker strategy using enol phosphonates

I. B. Campbell, J. Guo, E. Jones and Patrick. G. Steel, Org. Biomol. Chem., 2004, 2, 2725 DOI: 10.1039/B411111G

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