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Issue 5, 2004
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Planar lipid bilayer reconstitution with a micro-fluidic system

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Abstract

A planar lipid bilayer which is widely used for the electrophysiological study of membrane proteins in laboratories is reconstituted using a micro-fluidic system, in a manner that is suitable for automated processing. We fabricated micro-channels on both sides of the substrate, which are connected through a 100–200 μm aperture, and showed that the bilayer can be formed at the aperture by flowing the lipid solution and buffer, alternately. Parylene coating is found to be suitable for both bilayer formation and electric noise reduction. Future applications include a high-sensitivity ion sensor chip and a high-throughput drug screening device.

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Article information


Submitted
20 Apr 2004
Accepted
01 Jul 2004
First published
02 Sep 2004

Lab Chip, 2004,4, 502-505
Article type
Paper

Planar lipid bilayer reconstitution with a micro-fluidic system

H. Suzuki, K. Tabata, Y. Kato-Yamada, H. Noji and S. Takeuchi, Lab Chip, 2004, 4, 502
DOI: 10.1039/B405967K

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