Jump to main content
Jump to site search

Issue 5, 2004
Previous Article Next Article

Planar lipid bilayer reconstitution with a micro-fluidic system

Author affiliations


A planar lipid bilayer which is widely used for the electrophysiological study of membrane proteins in laboratories is reconstituted using a micro-fluidic system, in a manner that is suitable for automated processing. We fabricated micro-channels on both sides of the substrate, which are connected through a 100–200 μm aperture, and showed that the bilayer can be formed at the aperture by flowing the lipid solution and buffer, alternately. Parylene coating is found to be suitable for both bilayer formation and electric noise reduction. Future applications include a high-sensitivity ion sensor chip and a high-throughput drug screening device.

Back to tab navigation

Publication details

The article was received on 20 Apr 2004, accepted on 01 Jul 2004 and first published on 02 Sep 2004

Article type: Paper
DOI: 10.1039/B405967K
Lab Chip, 2004,4, 502-505

  •   Request permissions

    Planar lipid bilayer reconstitution with a micro-fluidic system

    H. Suzuki, K. Tabata, Y. Kato-Yamada, H. Noji and S. Takeuchi, Lab Chip, 2004, 4, 502
    DOI: 10.1039/B405967K

Search articles by author