Issue 12, 2004

Synthesis of methylethers by reaction of alcohols with dimethylcarbonate

Abstract

A new synthetic procedure to methylethers has been developed by the reaction of alcohols with dimethylcarbonate, a non-toxic and environmentally friendly reagent. The methylation of alcohols is catalysed by alumina or hydrotalcite. The methylcarbonate formed in the first step undergoes decarboxylation in the second step, to give the corresponding methylether. The reactivity follows the order: primary > secondary ≫ tertiary alcohols. The reaction can be efficiently performed under both batch and continuous flow conditions.

Graphical abstract: Synthesis of methylethers by reaction of alcohols with dimethylcarbonate

Article information

Article type
Paper
Submitted
18 Aug 2004
Accepted
23 Sep 2004
First published
02 Nov 2004

Green Chem., 2004,6, 609-612

Synthesis of methylethers by reaction of alcohols with dimethylcarbonate

P. Tundo, S. Memoli, D. Hérault and K. Hill, Green Chem., 2004, 6, 609 DOI: 10.1039/B412722F

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