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Issue 82, 2004

High-pressure recrystallisation—a route to new polymorphs and solvates

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Abstract

The recrystallisation of organic compounds from solution under high-pressure conditions is shown to be a versatile method for the formation of new polymorphs and solvates. The technique is illustrated by the crystallisation of a new polymorph of phenanthrene from dichloromethane at a pressure of 0.7 GPa, and the crystallisation of a novel dihydrate of paracetamol from water at a pressure of 1.1 GPa. These phases have been characterised by single crystal X-ray diffraction. We also demonstrate that the technique can be used to prepare a polymorph that is metastable under ambient conditions. Thus the orthorhombic form of paracetamol was crystallised from ethanol at a pressure of 1.1 GPa.

Graphical abstract: High-pressure recrystallisation—a route to new polymorphs and solvates

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Article information


Submitted
04 May 2004
Accepted
06 Jul 2004
First published
17 Sep 2004

CrystEngComm, 2004,6, 505-511
Article type
Paper

High-pressure recrystallisation—a route to new polymorphs and solvates

F. P. A. Fabbiani, D. R. Allan, W. I. F. David, S. A. Moggach, S. Parsons and C. R. Pulham, CrystEngComm, 2004, 6, 505
DOI: 10.1039/B406631F

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