Issue 21, 2004
From the journal:

Chemical Communications

Site-specific oxidative cleavage of DNA by metallosalen–DNA conjugates†

Jennifer L. Czlapinski‡a  and  Terry L. Sheppard*a  

* Corresponding authors

a Northwestern University, Department of Chemistry, 2145 Sheridan Road, Evanston, Illinois, USA
E-mail: t-sheppard@northwestern.edu
Fax: 847 491 7713
Tel: 847 467 7636

Abstract

Ni-salen–DNA conjugates, prepared by template-directed synthesis, targeted oxidative adduct formation and strand scission at deoxyguanosine sites in complementary DNA strands of Watson–Crick duplexes.

Graphical abstract: Site-specific oxidative cleavage of DNA by metallosalen–DNA conjugates

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Article information

DOI
https://doi.org/10.1039/B410493E
Article type
Communication
Submitted
09 Jul 2004
Accepted
05 Aug 2004
First published
24 Sep 2004

Chem. Commun., 2004, 2468-2469

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Site-specific oxidative cleavage of DNA by metallosalen–DNA conjugates

J. L. Czlapinski and T. L. Sheppard, Chem. Commun., 2004, 2468 DOI: 10.1039/B410493E

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