Issue 22, 2004

A simple, general and efficient ketone synthesis viaalkylation and dephosphinoylation of β-keto-diphenylphosphine oxides

Abstract

Products of difficult ketone alkylation reactions can be made selectively via activation with a diphenylphosphinoyl group; subsequent dephosphinoylation is easily achieved in base.

Graphical abstract: A simple, general and efficient ketone synthesis via alkylation and dephosphinoylation of β-keto-diphenylphosphine oxides

Supplementary files

Article information

Article type
Communication
Submitted
02 Jul 2004
Accepted
20 Aug 2004
First published
30 Sep 2004

Chem. Commun., 2004, 2598-2599

A simple, general and efficient ketone synthesis via alkylation and dephosphinoylation of β-keto-diphenylphosphine oxides

D. J. Fox, D. S. Pedersen and S. Warren, Chem. Commun., 2004, 2598 DOI: 10.1039/B410144H

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