Issue 21, 2004

Aziridine sulfides and disulfides as catalysts for the enantioselective addition of diethylzinc to aldehydes

Abstract

Chiral aziridine sulfides and disulfides were synthesized from readily available and inexpensive R-cysteine by a Mitsunobu reaction; their application in the addition of diethylzinc to aldehydes provides secondary alcohols with up to 99% ee and S-configuration.

Graphical abstract: Aziridine sulfides and disulfides as catalysts for the enantioselective addition of diethylzinc to aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
04 Jun 2004
Accepted
01 Jul 2004
First published
14 Sep 2004

Chem. Commun., 2004, 2488-2489

Aziridine sulfides and disulfides as catalysts for the enantioselective addition of diethylzinc to aldehydes

A. L. Braga, P. Milani, M. W. Paixão, G. Zeni, O. E. D. Rodrigues and E. F. Alves, Chem. Commun., 2004, 2488 DOI: 10.1039/B408537J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements