Issue 16, 2004
From the journal:

Chemical Communications

Concise asymmetric synthesis of (−)-sparteine†

Jean-Paul R. Hermet,a   Matthew J. McGrath,a   Peter O'Brien,*a   David W. Portera  and  John Gildayb  

* Corresponding authors

a Department of Chemistry, University of York, Heslington, York, UK
E-mail: paob1@york.ac.uk
Fax: +44 (0)1904 432516
Tel: +44 (0)1904 432535

b AstraZeneca, Process R & D, Avlon Works, Severn Road, Hallen, Bristol, UK

Abstract

A six-step asymmetric synthesis of natural (−)-sparteine from ethyl 7-iodohept-2-enoate is reported, involving a connective Michael addition of an amino ester-derived enolate to an α,β-unsaturated amino ester.

Graphical abstract: Concise asymmetric synthesis of (−)-sparteine

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B406632D
Article type
Communication
Submitted
05 May 2004
Accepted
02 Jun 2004
First published
21 Jul 2004

Chem. Commun., 2004, 1830-1831

Permissions

Request permissions

Concise asymmetric synthesis of (−)-sparteine

J. R. Hermet, M. J. McGrath, P. O'Brien, D. W. Porter and J. Gilday, Chem. Commun., 2004, 1830 DOI: 10.1039/B406632D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements