Issue 17, 2004
From the journal:

Chemical Communications

A single-enzyme, two-step, one-pot synthesis of N-substituted imidazole derivatives containing a glucose branch via combined acylation/Michael addition reaction†

Shi-Ping Yao,ab   De-Shui Lu,a   Qi Wu,a   Ying Cai,a   Shan-Hao Xua  and  Xian-Fu Lin*a  

* Corresponding authors

a Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China
E-mail: llc123@zju.edu.cn
Fax: 86 571 87952618
Tel: 86 571 87951588

b School of Chemistry and Chemical Engineering, Daqing Petroleum Institute, Daqing 163318, People's Republic of China
E-mail: ysp20042001@yahoo.com.cn
Tel: 86 459 6503788

Abstract

Combined regioselective acylation/Michael addition reaction catalyzed by alkaline protease from Bacillus subtilis in anhydrous pyridine for synthesis of N-substituted imidazole derivatives containing a glucose branch via a novel single-enzyme, two-step, one-pot procedure is reported.

Graphical abstract: A single-enzyme, two-step, one-pot synthesis of N-substituted imidazole derivatives containing a glucose branch via combined acylation/Michael addition reaction

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Article information

DOI
https://doi.org/10.1039/B405796A
Article type
Communication
Submitted
19 Apr 2004
Accepted
17 Jun 2004
First published
29 Jul 2004

Chem. Commun., 2004, 2006-2007

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A single-enzyme, two-step, one-pot synthesis of N-substituted imidazole derivatives containing a glucose branch via combined acylation/Michael addition reaction

S. Yao, D. Lu, Q. Wu, Y. Cai, S. Xu and X. Lin, Chem. Commun., 2004, 2006 DOI: 10.1039/B405796A

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