Issue 13, 2004
From the journal:

Chemical Communications

A stereodivergent asymmetric approach to difluorinated aldonic acids†

Christophe Audouard,a   Igor Barsukov,b   John Fawcett,a   Gerry A. Griffith,a   Jonathan M. Percy,*a   Stéphane Pintatc  and  Clive A. Smithd  

* Corresponding authors

a Department of Chemistry, University of Leicester, University Road, Leicester, UK
E-mail: jmp29@le.ac.uk
Fax: +44 116 252 3789
Tel: +44 116 252 2140

b Biological NMR Centre, University of Leicester, PO Box 138, University Road, Leicester, UK

c Evotech OAI, 151 Milton Park, Abingdon, Oxon, UK

d GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, UK

Abstract

A (bromodifluoromethyl)alkyne has been deployed in a stereoselective route to difluorinated aldonic acid analogues, in which a Sharpless asymmetric dihydroxylation reaction and diastereoisomer separation set the stage for phenyl group oxidation.

Graphical abstract: A stereodivergent asymmetric approach to difluorinated aldonic acids

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B405067C
Article type
Communication
Submitted
06 Apr 2004
Accepted
28 Apr 2004
First published
27 May 2004

Chem. Commun., 2004, 1526-1527

Permissions

Request permissions

A stereodivergent asymmetric approach to difluorinated aldonic acids

C. Audouard, I. Barsukov, J. Fawcett, G. A. Griffith, J. M. Percy, S. Pintat and C. A. Smith, Chem. Commun., 2004, 1526 DOI: 10.1039/B405067C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements