Issue 10, 2004

Unprecedented copper-catalyzed asymmetric conjugate addition of organometallic reagents to α,β-unsaturated lactams

Abstract

For the first time, an excellent enantioselectivity has been obtained in the conjugate addition of hard organometallic reagents to α,β-unsaturated lactams bearing appropriate protecting–activating groups on the nitrogen.

Graphical abstract: Unprecedented copper-catalyzed asymmetric conjugate addition of organometallic reagents to α,β-unsaturated lactams

Supplementary files

Article information

Article type
Communication
Submitted
11 Mar 2004
Accepted
06 Apr 2004
First published
28 Apr 2004

Chem. Commun., 2004, 1244-1245

Unprecedented copper-catalyzed asymmetric conjugate addition of organometallic reagents to α,β-unsaturated lactams

M. Pineschi, F. Del Moro, F. Gini, A. J. Minnaard and B. L. Feringa, Chem. Commun., 2004, 1244 DOI: 10.1039/B403793F

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