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Disulfide cross-linked oligonucleotides, which connect two different sequences of DNA strands, have been synthesized and characterized. Two double helices connected by two different cross-linked oligonucleotides can be arranged in both parallel and antiparallel orientations by addition of the specific complementary strands.

Graphical abstract: Structural arrangement of two DNA double helices using cross-linked oligonucleotide connectors

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