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Rate of the hydrolysis of bis(p-nitrophenyl) phosphate in 90% v/v aqueous DMSO increases 103–105 times in the presence of 1–2 mM alkaline-earth cations, which in the same concentration range do not affect the reaction rate in water.

Graphical abstract: Phosphodiesterolytic activity of alkaline-earth cations in aqueous DMSO

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