Issue 7, 2004
From the journal:

Chemical Communications

Novel model peptide for Atx1-like metallochaperones†

Olivier Sénèque,a   Serge Crouzy,b   Didier Boturyn,c   Pascal Dumy,c   Michel Ferrandb  and  Pascale Delangle*a  

* Corresponding authors

a Laboratoire de Reconnaissance Ionique, SCIB, CEA/DSM/DRFMC, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France
E-mail: delangle@cea.fr
Fax: (+33) 4 38 78 50 90
Tel: (+33) 4 38 78 98 22

b Laboratoire de Biophysique Moléculaire et Cellulaire (UMR 5090), CEA/DSV/DRDC, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France

c Laboratoire d'Etudes Dynamiques et Structurales de la Sélectivité (UMR 5616), Université Joseph Fourier, 301 rue de la Chimie, 38041 Grenoble Cedex 9, France

Abstract

The novel cyclodecapeptide c(GMTCSGCSRP) is able to bind soft metals with a selectivity for Hg2+ and Cu+ over Pb2+, Cd2+ and Zn2+, and is demonstrated to be an excellent structural model of the binding loop of the copper metallochaperone Atx1 in its apo and mercury loaded forms.

Graphical abstract: Novel model peptide for Atx1-like metallochaperones

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Article information

DOI
https://doi.org/10.1039/B315489K
Article type
Communication
Submitted
28 Nov 2003
Accepted
08 Jan 2004
First published
06 Feb 2004

Chem. Commun., 2004, 770-771

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Novel model peptide for Atx1-like metallochaperones

O. Sénèque, S. Crouzy, D. Boturyn, P. Dumy, M. Ferrand and P. Delangle, Chem. Commun., 2004, 770 DOI: 10.1039/B315489K

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