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Issue 2, 2004
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A concise stereocontrolled formal total synthesis of (±)-podophyllotoxin using sulfoxide chemistry

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Abstract

A short stereoselective formal total synthesis of (±)-podophyllotoxin has been carried out from a sulfoxide, using a one-pot tandem conjugate addition/aldol/electrophilic aromatic substitution reaction to form a tetralin, which was converted into picropodophyllin in two steps.

Graphical abstract: A concise stereocontrolled formal total synthesis of (±)-podophyllotoxin using sulfoxide chemistry

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Article information


Submitted
02 Oct 2003
Accepted
17 Nov 2003
First published
05 Dec 2003

Chem. Commun., 2004, 184-185
Article type
Communication

A concise stereocontrolled formal total synthesis of (±)-podophyllotoxin using sulfoxide chemistry

M. Casey and C. M. Keaveney, Chem. Commun., 2004, 184
DOI: 10.1039/B312245J

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