Issue 4, 2004
From the journal:

Organic & Biomolecular Chemistry

Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation–transmetalation–aldimine addition sequence†

Peter Wipf,ac   Jelena Janjicbc  and  Corey R. J. Stephensonac  

a Department of Chemistry, University of Pittsburgh, Pittsburgh Pennsylvania, 15260, USA
E-mail: pwipf@pitt.edu
Fax: +1-412-624-0787
Tel: +1-412-624-8606

b Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA

c Center for Chemical Methodologies & Library Development, University of Pittsburgh, Pittsburgh, PA 15260, USA

Abstract

The hydrozirconation of alkynes with zirconocene hydrochloride and the dimethylzinc-mediated addition of alkenylzirconocenes to diphenylphosphinoyl imines can be greatly accelerated with microwave irradiation, resulting in a convenient and rapid one-pot process for the preparation of synthetically useful allylic amines.

Graphical abstract: Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation–transmetalation–aldimine addition sequence

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B316741K
Article type
Communication
Submitted
23 Dec 2003
Accepted
19 Jan 2004
First published
28 Jan 2004

Org. Biomol. Chem., 2004,2, 443-445

Permissions

Request permissions

Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation–transmetalation–aldimine addition sequence

P. Wipf, J. Janjic and C. R. J. Stephenson, Org. Biomol. Chem., 2004, 2, 443 DOI: 10.1039/B316741K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements