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Issue 1, 2004
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Analysis of nickel species in cytosols of normal and malignant human colonic tissues using two dimensional liquid chromatography with ICP-sector field MS detection

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Abstract

A method has been developed that allows the nickel species in healthy and neoplastic tissues from cancer subjects to be compared. It is based on the coupling of sequentially applied anion-exchange and size-exclusion chromatography using an ICP-sector field mass spectrometer as detector. The method allows the resolution of seven nickel species in tissue extracts, which can be considered as fingerprints of nickel speciation. A qualitative difference in Ni-binding biomolecules between cytosols of normal and malignant colon tissues could not be found.

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Article information


Submitted
23 Jul 2003
Accepted
28 Oct 2003
First published
10 Dec 2003

J. Anal. At. Spectrom., 2004,19, 196-200
Article type
Technical Note

Analysis of nickel species in cytosols of normal and malignant human colonic tissues using two dimensional liquid chromatography with ICP-sector field MS detection

B. Bouyssiere, T. Knispel, C. Ruhnau, E. Denkhaus and A. Prange, J. Anal. At. Spectrom., 2004, 19, 196
DOI: 10.1039/B308607K

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