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Issue 4, 2004
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Palladium-free and ligand-free Sonogashira cross-coupling

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Abstract

Copper nanoclusters catalyse the cross-coupling of alkynes and aryl halides to give the corresponding disubstituted alkynes. No palladium, ligand, or co-catalyst is needed, and products are isolated in good yields (80–85%) and high selectivity. The clusters are simple to prepare, stable and can be applied to a variety of iodo- and bromoaryls. Mechanistic pathways for homocoupling and cross-coupling of alkynes are examined by comparing the activity of different catalyst and co-catalyst combinations. The copper clusters show different catalytic properties than their homogeneous analogues.

Graphical abstract: Palladium-free and ligand-free Sonogashira cross-coupling

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Article information


Submitted
03 Feb 2004
Accepted
03 Mar 2004
First published
19 Mar 2004

Green Chem., 2004,6, 215-218
Article type
Paper

Palladium-free and ligand-free Sonogashira cross-coupling

M. B. Thathagar, J. Beckers and G. Rothenberg, Green Chem., 2004, 6, 215
DOI: 10.1039/B401586J

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