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Issue 13, 2004
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Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases

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Abstract

A change of the prion protein conformation results in a class of neurodegenerative diseases called the transmissible spongiform encephalopathies (like mad cow and Creutzfeld–Jakob diseases). The function of the normal prion protein is unknown, although much of recent research demonstrates the it may be a copper binding protein selective for Cu(II). Amyloid precursor protein (APP) releases the 39–42 amino acid peptide, a major constituent of the deposit in plaques of Alzheimer disease brain. Also APP is a metal binding protein, including copper ions. The link between copper and both proteins may provide insight into the role of metals in neurodegenerative pathologies.

Graphical abstract: Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases

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Article information


Submitted
09 Feb 2004
Accepted
21 Apr 2004
First published
11 May 2004

Dalton Trans., 2004, 1907-1917
Article type
Perspective

Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases

D. R. Brown and H. Kozlowski, Dalton Trans., 2004, 1907
DOI: 10.1039/B401985G

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