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Issue 5, 2004
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Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(ii) complex

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Abstract

The axial aqua bound copper(II) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h−1 and a rate enhancement of 1.55 × 108.

Graphical abstract: Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(ii) complex

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Supplementary files

Article information


Submitted
29 Jan 2004
Accepted
02 Feb 2004
First published
05 Feb 2004

Dalton Trans., 2004, 697-698
Article type
Communication

Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(II) complex

S. Dhar, P. A. N. Reddy and A. R. Chakravarty, Dalton Trans., 2004, 697
DOI: 10.1039/B401383B

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