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Issue 20, 2004
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Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis

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Abstract

PCR primers designed to selectively amplify the unique C-methyltransferase domain of fungal polyketide synthases were used to selectively clone a polyketide synthase gene involved in the biosynthesis of the squalene synthase inhibitor squalestatin S1 1, heterologous expression of which led to the biosynthesis of the squalestatin side-chain.

Graphical abstract: Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis

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Publication details

The article was received on 04 Aug 2004, accepted on 03 Sep 2004 and first published on 24 Sep 2004


Article type: Communication
DOI: 10.1039/B411973H
Chem. Commun., 2004, 2260-2261

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    Rapid cloning and expression of a fungal polyketide synthase gene involved in squalestatin biosynthesis

    R. J. Cox, F. Glod, D. Hurley, C. M. Lazarus, Thomas. P. Nicholson, B. A. M. Rudd, T. J. Simpson, B. Wilkinson and Y. Zhang, Chem. Commun., 2004, 2260
    DOI: 10.1039/B411973H

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