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Issue 8, 2004
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SN2 vs. E2 on quaternary centres: an application to the synthesis of enantiopure β2,2-amino acids

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Abstract

SN2 and E2 competing reactions in cyclic sulfamidates can be modulated by the change of an amide group to an ester group attached to the quaternary carbon activated for the nucleophilic attack, allowing an easy approach to enantiopure α,α-disubstituted β-amino acids.

Graphical abstract: SN2 vs. E2 on quaternary centres: an application to the synthesis of enantiopure β2,2-amino acids

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Publication details

The article was received on 09 Jan 2004, accepted on 25 Feb 2004 and first published on 16 Mar 2004


Article type: Communication
DOI: 10.1039/B400282B
Chem. Commun., 2004, 980-981

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    SN2 vs. E2 on quaternary centres: an application to the synthesis of enantiopure β2,2-amino acids

    A. Avenoza, J. H. Busto, F. Corzana, G. Jiménez-Osés and J. M. Peregrina, Chem. Commun., 2004, 980
    DOI: 10.1039/B400282B

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