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Issue 8, 2004
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Electrocatalytic detection of thiols using an edge plane pyrolytic graphite electrode

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Abstract

The first example of using an edge plane pyrolytic graphite electrode in electroanalysis is reported as the determination of homocysteine, N-acetylcysteine, cysteine and glutathione is studied. The response of the electrode in the direct oxidation of thiol moieties is explored and found to be electrocatalytic producing a reduction in the overpotential while having enhanced signal-to-noise characteristics compared to glassy carbon and basal plane pyrolytic graphite electrodes. The effectiveness of the methodology is examined in the determination of cysteine species in a growth tissue media that contains a high number of common biological interferences. The advantageous properties of this electrode for thiol determination lie in its excellent catalytic activity, sensitivity and simplicity.

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Publication details

The article was received on 26 Apr 2004, accepted on 04 Jun 2004 and first published on 06 Jul 2004


Article type: Paper
DOI: 10.1039/B406276K
Analyst, 2004,129, 755-758

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    Electrocatalytic detection of thiols using an edge plane pyrolytic graphite electrode

    R. R. Moore, C. E. Banks and R. G. Compton, Analyst, 2004, 129, 755
    DOI: 10.1039/B406276K

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