2 Synthetic methods Part (v) Protecting groups

Abstract

This report surveys significant developments in the field of protecting group chemistry over the calendar year 2002. As the chemistry of protecting groups is vast, even within the limitation of one year, it would be impossible to provide a complete and comprehensive summary in the space allocated. We have therefore exercised a certain amount of discretion in selecting what we consider to be the most significant of the achievements in this area over 2002. To this end we have included sections on the developments of protecting group strategies for carbohydrates, peptides and DNA bases. We have also included a section on protecting groups in the synthesis of larger target molecules, trying where appropriate to highlight those cases where the protecting group influences the outcome of a reaction in either an anticipated or an unexpected manner (Section 9).