Structure-based design of carboxybiphenylindole inhibitors of the ZipA–FtsZ interaction

Alan G. Sutherland; Juan Alvarez; Weidong Ding; K. W. Foreman; Cynthia Hess Kenny; Pornpen Labthavikul; Lidia Mosyak; Peter J. Petersen; Thomas S. Rush III; Alexey Ruzin; Desiree H. H. Tsao; Karen L. Wheless

doi:10.1039/B312016C

Structure-based design of carboxybiphenylindole inhibitors of the ZipA–FtsZ interaction

Alan G. Sutherland,*^a Juan Alvarez,^b Weidong Ding,^a K. W. Foreman,^b Cynthia Hess Kenny,^a Pornpen Labthavikul,^c Lidia Mosyak,^b Peter J. Petersen,^c Thomas S. Rush III,^b Alexey Ruzin,^c Desiree H. H. Tsao^b and Karen L. Wheless^a

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^a Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA
E-mail: sutherag@wyeth.com
Fax: +01 845 602 5561
Tel: +01 845 602 3701

^b Chemical and Screening Sciences, Wyeth Research, Cambridge, MA 02140, USA

^c Infectious Diseases Biology, Wyeth Research, Pearl River, NY 10965, USA

Abstract

Structural features of two weak inhibitors of the ZipA–FtsZ protein–protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenylindoles with improved inhibitory activity.

Organic & Biomolecular Chemistry

Structure-based design of carboxybiphenylindole inhibitors of the ZipA–FtsZ interaction

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Structure-based design of carboxybiphenylindole inhibitors of the ZipA–FtsZ interaction

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