Issue 23, 2003
From the journal:

Organic & Biomolecular Chemistry

Solid-phase synthesis and characterization of a novel fullerene-peptide derived from histone H3

Alberto Bianco,*a   Davide Pantarotto,ab   Johan Hoebeke,a   Jean-Paul Brianda  and  Maurizio Pratob  

* Corresponding authors

a Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France
E-mail: A.Bianco@ibmc.u-strasbg.fr
Fax: +33 388 610680
Tel: +33 388 417088

b Department of Pharmaceutical Sciences, University of Trieste, 34127 Trieste, Italy

Abstract

A peptide analogue from a histone H3 protein containing the L-fulleropyrrolidino-glutamic acid has been prepared by a solid-phase approach and has been fully characterized. By molecular modelling it was verified that this peptide derivative is able to retain a binding capacity to the MHC (major histocompatibility complex) molecule similar to that of the cognate epitope.

Graphical abstract: Solid-phase synthesis and characterization of a novel fullerene-peptide derived from histone H3

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Article information

DOI
https://doi.org/10.1039/B311505D
Article type
Communication
Submitted
19 Sep 2003
Accepted
15 Oct 2003
First published
22 Oct 2003

Org. Biomol. Chem., 2003,1, 4141-4143

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Solid-phase synthesis and characterization of a novel fullerene-peptide derived from histone H3

A. Bianco, D. Pantarotto, J. Hoebeke, J. Briand and M. Prato, Org. Biomol. Chem., 2003, 1, 4141 DOI: 10.1039/B311505D

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