Issue 13, 2003

The synthesis of an isopropyl substituted 1,4,7-triazacyclononanevia an in situ sequential macrocyclisation method

Abstract

Using L-valine methyl ester hydrochloride as starting material, the synthesis of (2S)-2-isopropyl-1,4,7-trimethyl-1,4,7-triazacyclononane is described. Various standard Richman–Atkins cyclisation methods gave only poor yields in the key macrocyclisation step. Efficient macrocyclisation yields were, however, realised when an in situ sequential cyclisation method was developed.

Graphical abstract: The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method

Supplementary files

Article information

Article type
Paper
Submitted
14 Mar 2003
Accepted
12 May 2003
First published
22 May 2003

Org. Biomol. Chem., 2003,1, 2357-2363

The synthesis of an isopropyl substituted 1,4,7-triazacyclononane via an in situ sequential macrocyclisation method

G. Stones, G. Argouarch, A. R. Kennedy, D. C. Sherrington and C. L. Gibson, Org. Biomol. Chem., 2003, 1, 2357 DOI: 10.1039/B302887A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements