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The reaction of suitably disubstituted alkynes with diisopropyl xanthogen disulfide gives differentially substituted 4,5-disubstituted-1,3-dithiol-2-ones as proligands for metal complexes related to the molybdenum cofactor.

Graphical abstract: Synthesis of 1,3-dithiol-2-ones as proligands related to molybdopterin

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