Issue 1, 2003

Concise synthesis of (±)-horsfiline and (±)-coerulescine by tandem cyclisation of iodoaryl alkenyl azides

Abstract

A brief, efficient and economical synthesis of the spiropyrrolidinyloxindoles, horsfiline and coerulescine, has been achieved, starting from itaconic acid and, respectively, p-anisidine or o-iodoaniline. Tandem radical cyclisation of iodoaryl alkenyl azides is the key step in both syntheses.

Graphical abstract: Concise synthesis of (±)-horsfiline and (±)-coerulescine by tandem cyclisation of iodoaryl alkenyl azides

Supplementary files

Article information

Article type
Paper
Submitted
19 Aug 2002
Accepted
05 Sep 2002
First published
29 Nov 2002

Org. Biomol. Chem., 2003,1, 117-122

Concise synthesis of (±)-horsfiline and (±)-coerulescine by tandem cyclisation of iodoaryl alkenyl azides

D. E. Lizos and J. A. Murphy, Org. Biomol. Chem., 2003, 1, 117 DOI: 10.1039/B208114H

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