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Issue 3, 2003
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Diastereoselective conjugate addition of organocuprates to chiral racemic olefinic amido esters. Formal total synthesis of paroxetine

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Abstract

The diastereoselective conjugate addition of an organocopper reagent to a chiral racemic olefinic amido ester has been used as the key step in a formal total synthesis of paroxetine.

Graphical abstract: Diastereoselective conjugate addition of organocuprates to chiral racemic olefinic amido esters. Formal total synthesis of paroxetine

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Publication details

The article was received on 16 Sep 2002, accepted on 12 Nov 2002 and first published on 28 Jan 2003


Article type: Paper
DOI: 10.1039/B209181J
New J. Chem., 2003,27, 475-482

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    Diastereoselective conjugate addition of organocuprates to chiral racemic olefinic amido esters. Formal total synthesis of paroxetine

    J. Cossy, O. Mirguet, D. G. Pardo and J. Desmurs, New J. Chem., 2003, 27, 475
    DOI: 10.1039/B209181J

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