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Issue 12, 2003
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Microcontact printing of DNA-surfactant arrays on solid substrates

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Abstract

We have designed a novel method for fabrication of DNA arrays based on microcontact printing of DNA-surfactants on solid substrates. DNA-surfactants were prepared by covalent attachment of a hydrophobic anchoring group to the (3′- or 5′-) end of DNA oligonucleotides. This anchoring group allows DNA-strands to be immobilised on hydrophobic surfaces by hydrophobic interactions. The microcontact printing method was adapted for aqueous “inks” containing DNA-surfactants. Special attention was paid to the wetting properties of the ink with respect to the stamp and the solid substrates. The method allows for efficient attachment of DNA strands to solid surfaces and hybridisation with complementary DNA strands. This new technology could be utilised for rapid preparation of DNA-assays and genetic biochips.

Graphical abstract: Microcontact printing of DNA-surfactant arrays on solid substrates

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Article information


Submitted
09 Jul 2003
Accepted
27 Aug 2003
First published
09 Sep 2003

J. Mater. Chem., 2003,13, 3044-3048
Article type
Paper

Microcontact printing of DNA-surfactant arrays on solid substrates

C. Xu, P. Taylor, M. Ersoz, P. D. I. Fletcher and V. N. Paunov, J. Mater. Chem., 2003, 13, 3044
DOI: 10.1039/B307788H

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