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Issue 19, 2003
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Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate

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Abstract

Comparison of the kinetic and parallel kinetic resolutions of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate allows for the efficient synthesis of both (1R,2S,5S)- and (1S,2R,5R)-enantiomers of methyl 2-amino-5-tert-butyl-cyclopentane-1-carboxylate.

Graphical abstract: Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate

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Article information


Submitted
29 Jul 2003
Accepted
14 Aug 2003
First published
26 Aug 2003

Chem. Commun., 2003, 2410-2411
Article type
Communication

Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate

S. G. Davies, D. Díez, M. M. El Hammouni, A. Christopher Garner, N. M. Garrido, M. J. C. Long, R. M. Morrison, A. D. Smith, M. J. Sweet and J. M. Withey, Chem. Commun., 2003, 2410
DOI: 10.1039/B308855C

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