Gadolinium-binding helix–turn–helix peptides: DNA-dependent MRI contrast agents†
Abstract
A de novo designed gadolinium metallopeptide was found to be a very efficient relaxation agent, with 100% increase in relaxivity upon binding to DNA.
* Corresponding authors
a EPIX Medical, Inc., 71 Rogers Street, Cambridge, MA 02142, USA
b
Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA
E-mail:
sonya-franklin@uiowa.edu
Fax: 01 319-353-2244
Tel: 01 319-335-1270
A de novo designed gadolinium metallopeptide was found to be a very efficient relaxation agent, with 100% increase in relaxivity upon binding to DNA.
P. Caravan, J. M. Greenwood, J. T. Welch and S. J. Franklin, Chem. Commun., 2003, 2574 DOI: 10.1039/B307817E
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