Issue 20, 2003
From the journal:

Chemical Communications

Gadolinium-binding helix–turn–helix peptides: DNA-dependent MRI contrast agents†

Peter Caravan,a   Jaclyn M. Greenwood,a   Joel T. Welchb  and  Sonya J. Franklin*b  

* Corresponding authors

a EPIX Medical, Inc., 71 Rogers Street, Cambridge, MA 02142, USA

b Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA
E-mail: sonya-franklin@uiowa.edu
Fax: 01 319-353-2244
Tel: 01 319-335-1270

Abstract

A de novo designed gadolinium metallopeptide was found to be a very efficient relaxation agent, with 100% increase in relaxivity upon binding to DNA.

Graphical abstract: Gadolinium-binding helix–turn–helix peptides: DNA-dependent MRI contrast agents

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B307817E
Article type
Communication
Submitted
09 Jul 2003
Accepted
12 Aug 2003
First published
12 Sep 2003

Chem. Commun., 2003, 2574-2575

Permissions

Request permissions

Gadolinium-binding helix–turn–helix peptides: DNA-dependent MRI contrast agents

P. Caravan, J. M. Greenwood, J. T. Welch and S. J. Franklin, Chem. Commun., 2003, 2574 DOI: 10.1039/B307817E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements