Jump to main content
Jump to site search

Issue 19, 2003
Previous Article Next Article

Regioselective synthesis of 1,2,3-triazole derivatives via 1,3-dipolar cycloaddition reactions in water

Author affiliations

Abstract

Reaction of an arylacetylene with an azide in hot water gave 1,4-disubstituted 1,2,3-triazoles in high yields, while similar reaction between a terminal aliphatic alkyne and an azide (except m-nitroazidobenzene) afforded a mixture of regioisomers with the ratio of 1,4- to 1,5-isomers ranging from 3 : 1 to 28.6 : 1. Reactions of m-nitroazidobenzene with either arylalkynes or aliphatic alkynes formed only 1,4-disubstituted derivatives in excellent yields.

Graphical abstract: Regioselective synthesis of 1,2,3-triazole derivatives via 1,3-dipolar cycloaddition reactions in water

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Jun 2003, accepted on 13 Aug 2003 and first published on 22 Aug 2003


Article type: Communication
DOI: 10.1039/B307084K
Chem. Commun., 2003, 2450-2451

  •   Request permissions

    Regioselective synthesis of 1,2,3-triazole derivatives via 1,3-dipolar cycloaddition reactions in water

    Z. Wang and H. Qin, Chem. Commun., 2003, 2450
    DOI: 10.1039/B307084K

Search articles by author

Spotlight

Advertisements