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Issue 16, 2003
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Total synthesis of (+)-kalkitoxin

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Abstract

The neurotoxic lipopeptide (+)-kalkitoxin was synthesized by a route which employed asymmetric organocopper conjugate addition followed by in situ enolate alkylation to install the anti,anti-1,2,4-trimethyl relationship of the toxin; the synthesis of kalkitoxin required sixteen steps and proceeded in 3% overall yield.

Graphical abstract: Total synthesis of (+)-kalkitoxin

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Publication details

The article was received on 30 May 2003, accepted on 23 Jun 2003 and first published on 04 Jul 2003


Article type: Communication
DOI: 10.1039/B306124H
Citation: Chem. Commun., 2003,0, 2012-2013
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    Total synthesis of (+)-kalkitoxin

    J. D. White, C. Lee and Q. Xu, Chem. Commun., 2003, 0, 2012
    DOI: 10.1039/B306124H

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