Issue 16, 2003

Total synthesis of (+)-kalkitoxin

Abstract

The neurotoxic lipopeptide (+)-kalkitoxin was synthesized by a route which employed asymmetric organocopper conjugate addition followed by in situ enolate alkylation to install the anti,anti-1,2,4-trimethyl relationship of the toxin; the synthesis of kalkitoxin required sixteen steps and proceeded in 3% overall yield.

Graphical abstract: Total synthesis of (+)-kalkitoxin

Supplementary files

Article information

Article type
Communication
Submitted
30 May 2003
Accepted
23 Jun 2003
First published
04 Jul 2003

Chem. Commun., 2003, 2012-2013

Total synthesis of (+)-kalkitoxin

J. D. White, C. Lee and Q. Xu, Chem. Commun., 2003, 2012 DOI: 10.1039/B306124H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements