Issue 15, 2003
From the journal:

Chemical Communications

Synthesis and biological evaluation of cytostatin analogues†

Laurent Bialy*ab  and  Herbert Waldmannab  

* Corresponding authors

a Max-Planck-Institut für molekulare Physiologie, Abteilung Chemische Biologie, Otto-Hahn-Str. 11, 44227 Dortmund, Germany
E-mail: herbert.waldmann@mpi-dortmund.mpg.de
Fax: 49 231 133 2499
Tel: 49 231 133 2400

b Universität Dortmund, Fachbereich 3, Organische Chemie, 44221 Dortmund, Germany

Abstract

Analogues of the serine/threonine phosphatase 2A inhibitor cytostatin were synthesized and evaluated as inhibitors of various phosphatases in order to establish a basic structure–activity relationship (SAR) of the natural product.

Graphical abstract: Synthesis and biological evaluation of cytostatin analogues

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Article information

DOI
https://doi.org/10.1039/B305308N
Article type
Communication
Submitted
12 May 2003
Accepted
03 Jun 2003
First published
20 Jun 2003

Chem. Commun., 2003, 1872-1873

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Synthesis and biological evaluation of cytostatin analogues

L. Bialy and H. Waldmann, Chem. Commun., 2003, 1872 DOI: 10.1039/B305308N

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